American Airlines flights from Key West to Charleston, SC

Recent searches for flights from Key West to Charleston, SC

Aug 2026
From$445*
Updated: 10 hours ago
Round tripIEconomy
Sep 2026
From$341*
Updated: 10 hours ago
Round tripIEconomy
Oct 2026
From$341*
Updated: 19 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $393
cmp-daily-histogram-bars-legend-max-price-aria-label $901
Displaying fares for August-2026
  • EYW–CHS, 08/22/26 – 08/29/26: From $445
    22

    Sa

    AUG

  • EYW–CHS, 08/23/26 – 08/30/26: From $603
    23

    Su

  • EYW–CHS, 08/24/26 – 08/31/26: From $603
    24

    Mo

  • EYW–CHS, 08/25/26 – 09/01/26: From $445
    25

    Tu

  • EYW–CHS, 08/26/26 – 09/02/26: From $445
    26

    We

  • EYW–CHS, 08/27/26 – 09/03/26: From $603
    27

    Th

  • EYW–CHS, 08/28/26 – 09/04/26: From $627
    28

    Fr

  • EYW–CHS, 08/29/26 – 09/05/26: From $469
    29

    Sa

  • EYW–CHS, 08/30/26 – 09/06/26: From $581
    30

    Su

  • EYW–CHS, 08/31/26 – 09/07/26: From $581
    31

    Mo

  • EYW–CHS, 09/01/26 – 09/08/26: From $445
    01

    Tu

    SEP

  • EYW–CHS, 09/02/26 – 09/09/26: From $445
    02

    We

  • EYW–CHS, 09/03/26 – 09/10/26: From $590
    03

    Th

  • EYW–CHS, 09/04/26 – 09/11/26: From $581
    04

    Fr

  • EYW–CHS, 09/05/26 – 09/12/26: From $393
    05

    Sa

  • EYW–CHS, 09/06/26 – 09/13/26: From $477
    06

    Su

  • EYW–CHS, 09/07/26 – 09/14/26: From $901
    07

    Mo

  • EYW–CHS, 09/08/26 – 09/15/26: From $568
    08

    Tu

  • EYW–CHS, 09/09/26 – 09/16/26: From $393
    09

    We

  • EYW–CHS, 09/10/26 – 09/17/26: From $490
    10

    Th

  • EYW–CHS, 09/11/26 – 09/18/26: From $399
    11

    Fr

  • EYW–CHS, 09/12/26 – 09/19/26: From $393
    12

    Sa

  • EYW–CHS, 09/13/26 – 09/20/26: From $621
    13

    Su

  • EYW–CHS, 09/14/26 – 09/21/26: From $447
    14

    Mo

  • EYW–CHS, 09/15/26 – 09/22/26: From $393
    15

    Tu

  • EYW–CHS, 09/16/26 – 09/23/26: From $431
    16

    We

  • EYW–CHS, 09/17/26 – 09/24/26: From $594
    17

    Th

  • EYW–CHS, 09/18/26 – 09/25/26: From $447
    18

    Fr

  • EYW–CHS: cmp-view-offers-disclaimer. Find Offers
    19

    Sa

  • EYW–CHS: cmp-view-offers-disclaimer. Find Offers
    20

    Su

  • EYW–CHS, 09/21/26 – 09/28/26: From $437
    21

    Mo

    • range$393-$901

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Key West to Charleston, SC flights

    $
    keyboard_arrow_down

    Key West (EYW)to

    Charleston, SC (CHS)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 19 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    Key West (EYW)to

    Charleston, SC (CHS)
    11/11/26 - 11/18/26

    Round trip

    Economy

    from
    $341Fare subject to changes
    Updated: 10 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Key West to Charleston, SC

    Looking for lower fares on your trip from Key West to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Key West to Charleston, SC