American Airlines flights from Key West to Knoxville

Recent searches for flights from Key West to Knoxville

Sep 2026
From$354*
Updated: 14 hours ago
Round tripIEconomy
Oct 2026
From$339*
Updated: 14 hours ago
Round tripIEconomy
Nov 2026
From$339*
Updated: 14 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $339
cmp-daily-histogram-bars-legend-max-price-aria-label $899
Displaying fares for September-2026
  • EYW–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Su

    SEP

  • EYW–TYS, 09/14/26 – 09/21/26: From $444
    14

    Mo

  • EYW–TYS, 09/15/26 – 09/22/26: From $444
    15

    Tu

  • EYW–TYS, 09/16/26 – 09/23/26: From $444
    16

    We

  • EYW–TYS, 09/17/26 – 09/24/26: From $653
    17

    Th

  • EYW–TYS, 09/18/26 – 09/25/26: From $601
    18

    Fr

  • EYW–TYS, 09/19/26 – 09/26/26: From $444
    19

    Sa

  • EYW–TYS, 09/20/26 – 09/27/26: From $752
    20

    Su

  • EYW–TYS, 09/21/26 – 09/28/26: From $399
    21

    Mo

  • EYW–TYS, 09/22/26 – 09/29/26: From $399
    22

    Tu

  • EYW–TYS, 09/23/26 – 09/30/26: From $399
    23

    We

  • EYW–TYS, 09/24/26 – 10/01/26: From $693
    24

    Th

  • EYW–TYS, 09/25/26 – 10/02/26: From $899
    25

    Fr

  • EYW–TYS, 09/26/26 – 10/03/26: From $892
    26

    Sa

  • EYW–TYS, 09/27/26 – 10/04/26: From $899
    27

    Su

  • EYW–TYS, 09/28/26 – 10/05/26: From $556
    28

    Mo

  • EYW–TYS, 09/29/26 – 10/06/26: From $354
    29

    Tu

  • EYW–TYS, 09/30/26 – 10/07/26: From $354
    30

    We

  • EYW–TYS, 10/01/26 – 10/08/26: From $419
    01

    Th

    OCT

  • EYW–TYS, 10/02/26 – 10/09/26: From $354
    02

    Fr

  • EYW–TYS, 10/03/26 – 10/10/26: From $354
    03

    Sa

  • EYW–TYS, 10/04/26 – 10/11/26: From $622
    04

    Su

  • EYW–TYS, 10/05/26 – 10/12/26: From $339
    05

    Mo

  • EYW–TYS, 10/06/26 – 10/13/26: From $339
    06

    Tu

  • EYW–TYS, 10/07/26 – 10/14/26: From $339
    07

    We

  • EYW–TYS, 10/08/26 – 10/15/26: From $339
    08

    Th

  • EYW–TYS, 10/09/26 – 10/16/26: From $556
    09

    Fr

  • EYW–TYS, 10/10/26 – 10/17/26: From $764
    10

    Sa

  • EYW–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Su

  • EYW–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Mo

    • range$339-$899

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Key West to Knoxville flights

    $
    keyboard_arrow_down

    Key West (EYW)to

    Knoxville (TYS)
    10/05/26 - 10/12/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    10/07/26 - 10/14/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    10/16/26 - 10/23/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    10/19/26 - 10/26/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    12/07/26 - 12/14/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    Key West (EYW)to

    Knoxville (TYS)
    11/17/26 - 11/24/26

    Round trip

    Economy

    from
    $339Fare subject to changes
    Updated: 14 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Key West to Knoxville

    Looking for lower fares on your trip from Key West to Knoxville? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    American Airlines flights from Key West to Knoxville