American Airlines flights from Portland, ME to Destin

Recent searches for flights from Portland, ME to Destin

Sep 2026
From$512*
Updated: 4 hours ago
Round tripIEconomy
Oct 2026
From$429*
Updated: 4 hours ago
Round tripIEconomy
Nov 2026
From$429*
Updated: 4 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $472
cmp-daily-histogram-bars-legend-max-price-aria-label $1.0K
Displaying fares for September-2026
  • PWM–VPS, 09/12/26 – 09/19/26: From $927
    12

    Sa

    SEP

  • PWM–VPS, 09/13/26 – 09/20/26: From $1,030
    13

    Su

  • PWM–VPS, 09/14/26 – 09/21/26: From $1,030
    14

    Mo

  • PWM–VPS, 09/15/26 – 09/22/26: From $919
    15

    Tu

  • PWM–VPS, 09/16/26 – 09/23/26: From $905
    16

    We

  • PWM–VPS, 09/17/26 – 09/24/26: From $1,030
    17

    Th

  • PWM–VPS, 09/18/26 – 09/25/26: From $925
    18

    Fr

  • PWM–VPS, 09/19/26 – 09/26/26: From $818
    19

    Sa

  • PWM–VPS, 09/20/26 – 09/27/26: From $818
    20

    Su

  • PWM–VPS, 09/21/26 – 09/28/26: From $818
    21

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  • PWM–VPS, 09/22/26 – 09/29/26: From $818
    22

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  • PWM–VPS, 09/23/26 – 09/30/26: From $818
    23

    We

  • PWM–VPS, 09/24/26 – 10/01/26: From $811
    24

    Th

  • PWM–VPS, 09/25/26 – 10/02/26: From $562
    25

    Fr

  • PWM–VPS, 09/26/26 – 10/03/26: From $562
    26

    Sa

  • PWM–VPS, 09/27/26 – 10/04/26: From $798
    27

    Su

  • PWM–VPS, 09/28/26 – 10/05/26: From $512
    28

    Mo

  • PWM–VPS, 09/29/26 – 10/06/26: From $512
    29

    Tu

  • PWM–VPS, 09/30/26 – 10/07/26: From $534
    30

    We

  • PWM–VPS, 10/01/26 – 10/08/26: From $791
    01

    Th

    OCT

  • PWM–VPS, 10/02/26 – 10/09/26: From $528
    02

    Fr

  • PWM–VPS, 10/03/26 – 10/10/26: From $472
    03

    Sa

  • PWM–VPS, 10/04/26 – 10/11/26: From $721
    04

    Su

  • PWM–VPS, 10/05/26 – 10/12/26: From $791
    05

    Mo

  • PWM–VPS, 10/06/26 – 10/13/26: From $522
    06

    Tu

  • PWM–VPS, 10/07/26 – 10/14/26: From $478
    07

    We

  • PWM–VPS, 10/08/26 – 10/15/26: From $712
    08

    Th

  • PWM–VPS: cmp-view-offers-disclaimer. Find Offers
    09

    Fr

  • PWM–VPS: cmp-view-offers-disclaimer. Find Offers
    10

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  • PWM–VPS: cmp-view-offers-disclaimer. Find Offers
    11

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    • range$472-$1,030

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Portland, ME to Destin flights

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    Portland, ME (PWM)to

    Destin (VPS)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    10/23/26 - 10/30/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    10/30/26 - 11/06/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    12/02/26 - 12/09/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    12/04/26 - 12/11/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    12/07/26 - 12/14/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    Portland, ME (PWM)to

    Destin (VPS)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $429Fare subject to changes
    Updated: 4 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Portland, ME to Destin

    Looking for lower fares on your trip from Portland, ME to Destin? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

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    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Portland, ME to Destin