American Airlines flights from Saint Louis to Destin

Recent searches for flights from Saint Louis to Destin

Aug 2026
From$433*
Updated: 8 hours ago
Round tripIEconomy
Sep 2026
From$245*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$245*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $245
cmp-daily-histogram-bars-legend-max-price-aria-label $855
Displaying fares for August-2026
  • STL–VPS, 08/27/26 – 09/03/26: From $433
    27

    Th

    AUG

  • STL–VPS, 08/28/26 – 09/04/26: From $433
    28

    Fr

  • STL–VPS, 08/29/26 – 09/05/26: From $433
    29

    Sa

  • STL–VPS, 08/30/26 – 09/06/26: From $433
    30

    Su

  • STL–VPS, 08/31/26 – 09/07/26: From $855
    31

    Mo

  • STL–VPS, 09/01/26 – 09/08/26: From $440
    01

    Tu

    SEP

  • STL–VPS, 09/02/26 – 09/09/26: From $433
    02

    We

  • STL–VPS, 09/03/26 – 09/10/26: From $433
    03

    Th

  • STL–VPS, 09/04/26 – 09/11/26: From $570
    04

    Fr

  • STL–VPS, 09/05/26 – 09/12/26: From $433
    05

    Sa

  • STL–VPS, 09/06/26 – 09/13/26: From $545
    06

    Su

  • STL–VPS, 09/07/26 – 09/14/26: From $433
    07

    Mo

  • STL–VPS, 09/08/26 – 09/15/26: From $433
    08

    Tu

  • STL–VPS, 09/09/26 – 09/16/26: From $433
    09

    We

  • STL–VPS, 09/10/26 – 09/17/26: From $340
    10

    Th

  • STL–VPS, 09/11/26 – 09/18/26: From $361
    11

    Fr

  • STL–VPS, 09/12/26 – 09/19/26: From $431
    12

    Sa

  • STL–VPS, 09/13/26 – 09/20/26: From $433
    13

    Su

  • STL–VPS, 09/14/26 – 09/21/26: From $361
    14

    Mo

  • STL–VPS, 09/15/26 – 09/22/26: From $340
    15

    Tu

  • STL–VPS, 09/16/26 – 09/23/26: From $340
    16

    We

  • STL–VPS, 09/17/26 – 09/24/26: From $483
    17

    Th

  • STL–VPS, 09/18/26 – 09/25/26: From $357
    18

    Fr

  • STL–VPS, 09/19/26 – 09/26/26: From $245
    19

    Sa

  • STL–VPS, 09/20/26 – 09/27/26: From $483
    20

    Su

  • STL–VPS, 09/21/26 – 09/28/26: From $286
    21

    Mo

  • STL–VPS, 09/22/26 – 09/29/26: From $245
    22

    Tu

  • STL–VPS, 09/23/26 – 09/30/26: From $245
    23

    We

  • STL–VPS: cmp-view-offers-disclaimer. Find Offers
    24

    Th

  • STL–VPS: cmp-view-offers-disclaimer. Find Offers
    25

    Fr

  • STL–VPS, 09/26/26 – 10/03/26: From $286
    26

    Sa

    • range$245-$855

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Saint Louis to Destin flights

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    Saint Louis (STL)to

    Destin (VPS)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    10/29/26 - 11/05/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    10/17/26 - 10/24/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    09/19/26 - 09/26/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    Saint Louis (STL)to

    Destin (VPS)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $245Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Saint Louis to Destin

    Looking for lower fares on your trip from Saint Louis to Destin? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Saint Louis to Destin