American Airlines flights from Sioux Falls to Destin

Recent searches for flights from Sioux Falls to Destin

Aug 2026
From$471*
Updated: 6 hours ago
Round tripIEconomy
Sep 2026
From$427*
Updated: 6 hours ago
Round tripIEconomy
Oct 2026
From$427*
Updated: 6 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $471
cmp-daily-histogram-bars-legend-max-price-aria-label $1.1K
Displaying fares for August-2026
  • FSD–VPS, 08/01/26 – 08/08/26: From $924
    01

    Sa

    AUG

  • FSD–VPS, 08/02/26 – 08/09/26: From $1,080
    02

    Su

  • FSD–VPS, 08/03/26 – 08/10/26: From $666
    03

    Mo

  • FSD–VPS, 08/04/26 – 08/11/26: From $529
    04

    Tu

  • FSD–VPS, 08/05/26 – 08/12/26: From $535
    05

    We

  • FSD–VPS, 08/06/26 – 08/13/26: From $659
    06

    Th

  • FSD–VPS, 08/07/26 – 08/14/26: From $627
    07

    Fr

  • FSD–VPS, 08/08/26 – 08/15/26: From $595
    08

    Sa

  • FSD–VPS, 08/09/26 – 08/16/26: From $849
    09

    Su

  • FSD–VPS, 08/10/26 – 08/17/26: From $627
    10

    Mo

  • FSD–VPS, 08/11/26 – 08/18/26: From $529
    11

    Tu

  • FSD–VPS, 08/12/26 – 08/19/26: From $529
    12

    We

  • FSD–VPS, 08/13/26 – 08/20/26: From $627
    13

    Th

  • FSD–VPS, 08/14/26 – 08/21/26: From $555
    14

    Fr

  • FSD–VPS, 08/15/26 – 08/22/26: From $522
    15

    Sa

  • FSD–VPS, 08/16/26 – 08/23/26: From $555
    16

    Su

  • FSD–VPS, 08/17/26 – 08/24/26: From $555
    17

    Mo

  • FSD–VPS, 08/18/26 – 08/25/26: From $522
    18

    Tu

  • FSD–VPS, 08/19/26 – 08/26/26: From $522
    19

    We

  • FSD–VPS, 08/20/26 – 08/27/26: From $555
    20

    Th

  • FSD–VPS, 08/21/26 – 08/28/26: From $515
    21

    Fr

  • FSD–VPS, 08/22/26 – 08/29/26: From $515
    22

    Sa

  • FSD–VPS, 08/23/26 – 08/30/26: From $505
    23

    Su

  • FSD–VPS, 08/24/26 – 08/31/26: From $505
    24

    Mo

  • FSD–VPS, 08/25/26 – 09/01/26: From $471
    25

    Tu

  • FSD–VPS, 08/26/26 – 09/02/26: From $471
    26

    We

  • FSD–VPS, 08/27/26 – 09/03/26: From $505
    27

    Th

  • FSD–VPS, 08/28/26 – 09/04/26: From $505
    28

    Fr

  • FSD–VPS: cmp-view-offers-disclaimer. Find Offers
    29

    Sa

  • FSD–VPS: cmp-view-offers-disclaimer. Find Offers
    30

    Su

  • FSD–VPS, 08/31/26 – 09/07/26: From $584
    31

    Mo

    • range$471-$1,080

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Sioux Falls to Destin flights

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    Sioux Falls (FSD)to

    Destin (VPS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    09/02/26 - 09/09/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    09/15/26 - 09/22/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    09/16/26 - 09/23/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    Sioux Falls (FSD)to

    Destin (VPS)
    09/23/26 - 09/30/26

    Round trip

    Economy

    from
    $427Fare subject to changes
    Updated: 6 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Sioux Falls to Destin

    Looking for lower fares on your trip from Sioux Falls to Destin? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Sioux Falls to Destin