American Airlines flights from Destin to Charleston, SC

Recent searches for flights from Destin to Charleston, SC

Aug 2026
From$346*
Updated: 8 hours ago
Round tripIEconomy
Sep 2026
From$277*
Updated: 8 hours ago
Round tripIEconomy
Oct 2026
From$277*
Updated: 8 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $277
cmp-daily-histogram-bars-legend-max-price-aria-label $670
Displaying fares for August-2026
  • VPS–CHS: cmp-view-offers-disclaimer. Find Offers
    15

    Sa

    AUG

  • VPS–CHS, 08/16/26 – 08/23/26: From $670
    16

    Su

  • VPS–CHS, 08/17/26 – 08/24/26: From $670
    17

    Mo

  • VPS–CHS, 08/18/26 – 08/25/26: From $533
    18

    Tu

  • VPS–CHS, 08/19/26 – 08/26/26: From $533
    19

    We

  • VPS–CHS, 08/20/26 – 08/27/26: From $670
    20

    Th

  • VPS–CHS, 08/21/26 – 08/28/26: From $670
    21

    Fr

  • VPS–CHS, 08/22/26 – 08/29/26: From $474
    22

    Sa

  • VPS–CHS, 08/23/26 – 08/30/26: From $587
    23

    Su

  • VPS–CHS, 08/24/26 – 08/31/26: From $587
    24

    Mo

  • VPS–CHS, 08/25/26 – 09/01/26: From $474
    25

    Tu

  • VPS–CHS, 08/26/26 – 09/02/26: From $474
    26

    We

  • VPS–CHS, 08/27/26 – 09/03/26: From $641
    27

    Th

  • VPS–CHS, 08/28/26 – 09/04/26: From $641
    28

    Fr

  • VPS–CHS, 08/29/26 – 09/05/26: From $346
    29

    Sa

  • VPS–CHS, 08/30/26 – 09/06/26: From $427
    30

    Su

  • VPS–CHS, 08/31/26 – 09/07/26: From $583
    31

    Mo

  • VPS–CHS, 09/01/26 – 09/08/26: From $346
    01

    Tu

    SEP

  • VPS–CHS, 09/02/26 – 09/09/26: From $346
    02

    We

  • VPS–CHS, 09/03/26 – 09/10/26: From $368
    03

    Th

  • VPS–CHS, 09/04/26 – 09/11/26: From $380
    04

    Fr

  • VPS–CHS, 09/05/26 – 09/12/26: From $277
    05

    Sa

  • VPS–CHS, 09/06/26 – 09/13/26: From $387
    06

    Su

  • VPS–CHS, 09/07/26 – 09/14/26: From $621
    07

    Mo

  • VPS–CHS, 09/08/26 – 09/15/26: From $368
    08

    Tu

  • VPS–CHS, 09/09/26 – 09/16/26: From $277
    09

    We

  • VPS–CHS, 09/10/26 – 09/17/26: From $427
    10

    Th

  • VPS–CHS, 09/11/26 – 09/18/26: From $301
    11

    Fr

  • VPS–CHS: cmp-view-offers-disclaimer. Find Offers
    12

    Sa

  • VPS–CHS: cmp-view-offers-disclaimer. Find Offers
    13

    Su

  • VPS–CHS: cmp-view-offers-disclaimer. Find Offers
    14

    Mo

    • range$277-$670

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Destin to Charleston, SC flights

    $
    keyboard_arrow_down

    Destin (VPS)to

    Charleston, SC (CHS)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    09/26/26 - 10/03/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    10/03/26 - 10/10/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    10/10/26 - 10/17/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    Destin (VPS)to

    Charleston, SC (CHS)
    09/09/26 - 09/16/26

    Round trip

    Economy

    from
    $277Fare subject to changes
    Updated: 8 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Destin to Charleston, SC

    Looking for lower fares on your trip from Destin to Charleston, SC? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Destin to Charleston, SC