American Airlines flights to Knoxville from $159*

Popular flights to Knoxville on American Airlines

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  • Phoenix (PHX)to

    Knoxville (TYS)
    05/28/25 - 05/31/25
    from
    $229Fare subject to changes
    Updated: 1 hour ago
    Round trip
    I
    Economy

    New York (LGA)to

    Knoxville (TYS)
    07/30/25 - 08/06/25
    from
    $179Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Austin (AUS)to

    Knoxville (TYS)
    07/01/25 - 07/08/25
    from
    $220Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Miami (MIA)to

    Knoxville (TYS)
    07/29/25 - 08/05/25
    from
    $159Fare subject to changes
    Updated: 3 hours ago
    Round trip
    I
    Economy

  • Omaha (OMA)to

    Knoxville (TYS)
    07/01/25 - 07/08/25
    from
    $224Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

    Orlando (MCO)to

    Knoxville (TYS)
    08/12/25 - 08/19/25
    from
    $241Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Ontario (ONT)to

    Knoxville (TYS)
    07/04/25 - 07/11/25
    from
    $283Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Los Angeles (LAX)to

    Knoxville (TYS)
    07/08/25 - 07/15/25
    from
    $299Fare subject to changes
    Updated: 3 hours ago
    Round trip
    I
    Economy

  • San Francisco (SFO)to

    Knoxville (TYS)
    07/05/25 - 07/12/25
    from
    $293Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Orange County (SNA)to

    Knoxville (TYS)
    07/01/25 - 07/08/25
    from
    $283Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    San Diego (SAN)to

    Knoxville (TYS)
    06/25/25 - 07/02/25
    from
    $277Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Baltimore (BWI)to

    Knoxville (TYS)
    07/01/25 - 07/08/25
    from
    $214Fare subject to changes
    Updated: 3 hours ago
    Round trip
    I
    Economy

  • Seattle (SEA)to

    Knoxville (TYS)
    08/07/25 - 08/11/25
    from
    $377Fare subject to changes
    Updated: 3 hours ago
    Round trip
    I
    Economy

    Sacramento (SMF)to

    Knoxville (TYS)
    07/04/25 - 07/11/25
    from
    $279Fare subject to changes
    Updated: 1 hour ago
    Round trip
    I
    Economy

    San Antonio (SAT)to

    Knoxville (TYS)
    07/26/25 - 08/02/25
    from
    $217Fare subject to changes
    Updated: 2 hours ago
    Round trip
    I
    Economy

    Charlotte (CLT)to

    Knoxville (TYS)
    05/28/25 - 05/29/25
    from
    $347Fare subject to changes
    Updated: 6 hours ago
    Round trip
    I
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights to Knoxville from **Flights.FromLowestPrice***

Find deals on flights to Knoxville

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Dallas (DFW)to

Knoxville (TYS)
07/10/25 - 07/11/25

Round trip

I

Economy

from
$259Fare subject to changes
Updated: 8 hours ago

Philadelphia (PHL)to

Knoxville (TYS)
07/05/25 - 07/09/25

Round trip

I

Economy

from
$351Fare subject to changes
Updated: 43 minutes ago

Chicago (ORD)to

Knoxville (TYS)
07/25/25 - 08/01/25

Round trip

I

Economy

from
$189Fare subject to changes
Updated: 4 hours ago

Washington, D.C. (DCA)to

Knoxville (TYS)
07/04/25 - 07/11/25

Round trip

I

Economy

from
$184Fare subject to changes
Updated: 3 hours ago

Phoenix (PHX)to

Knoxville (TYS)
07/01/25 - 07/08/25

Round trip

I

Economy

from
$259Fare subject to changes
Updated: 3 hours ago

New York (LGA)to

Knoxville (TYS)
07/22/25 - 07/29/25

Round trip

I

Economy

from
$179Fare subject to changes
Updated: 2 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Knoxville routes with American Airlines