American Airlines flights to Knoxville from $159*

Popular flights to Knoxville on American Airlines

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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Visit Knoxville, Tennessee

Looking for flights to Knoxville, Tennessee? American Airlines supports your travel plans with service from major cities like Charlotte, Dallas-Fort Worth, Washington, D.C., Chicago and Miami. Choose from our range of travel schedules to Knoxville, whether you're heading for a business trip downtown or to explore the nearby Great Smoky Mountains. Check out popular flights to Knoxville and book your next trip with American today.

Find deals on flights to Knoxville

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Dallas (DFW)to

Knoxville (TYS)
09/15/25 - 09/20/25

Round trip

Economy

from
$325Fare subject to changes
Updated: 1 hour ago

Philadelphia (PHL)to

Knoxville (TYS)
11/01/25 - 11/08/25

Round trip

Economy

from
$355Fare subject to changes
Updated: 22 minutes ago

Miami (MIA)to

Knoxville (TYS)
09/09/25 - 09/16/25

Round trip

Economy

from
$159Fare subject to changes
Updated: 55 minutes ago

Washington, D.C. (DCA)to

Knoxville (TYS)
10/21/25 - 10/28/25

Round trip

Economy

from
$189Fare subject to changes
Updated: 10 hours ago

Chicago (ORD)to

Knoxville (TYS)
09/23/25 - 09/30/25

Round trip

Economy

from
$189Fare subject to changes
Updated: 11 hours ago

New York (LGA)to

Knoxville (TYS)
09/17/25 - 09/24/25

Round trip

Economy

from
$183Fare subject to changes
Updated: 10 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Tips for finding cheap flights to Knoxville

You have several ways to make your trip more affordable and make the most of your time in Knoxville.

  • Book early: Booking 1 to 3 months in advance can help you find lower fares to Knoxville.
  • Be flexible with dates: Tuesdays and Wednesdays typically offer lower airfare.
  • Travel off-peak: Mid-January to early March and late summer usually bring fewer visitors and better prices.

Upgrade your flight with Main Cabin Extra

Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

  • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
  • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
  • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

Discover how Main Cabin Extra can enhance your trip.

American Airlines flights to Knoxville from **Flights.FromLowestPrice***

Which airport in Knoxville does American Airlines fly to?

American flies into McGhee Tyson Airport (TYS), located about 12 miles south of downtown Knoxville. The airport is a gateway to the city's business core, local universities and scenic routes into the Smoky Mountains.

Getting from McGhee Tyson Airport to downtown Knoxville 

From TYS, several transportation options are available to connect you with your hotel, meeting location or favorite spots in and around Knoxville.

  • Public transportation: Limited bus service is available to select destinations. Check local routes for the latest schedules. 
  • Taxis / rideshare: Taxi and rideshare services are available curbside at the terminal. 
  • Hotel shuttles: Many hotels offer pre-arranged shuttle service so confirm directly with your stay. 
  • Rental cars: Major rental agencies operate on-site with access from the terminal. 

Check out TYS Airport's official website for more transportation details. 

Discover Knoxville 

Best time to visit Knoxville 

Knoxville offers 4 distinct seasons, each with something unique to offer travelers, including music, sports, festivals and fall colors. 

  • Spring (March – May): Spring welcomes blooming dogwoods and the start of the festival season, making it scenic and fun-filled. 
  • Fall (September – November): Crisp air and colorful foliage attract visitors for hiking, football weekends and local events. 

Keep in mind:

  • Summer (June – August): Warm weather pairs well with riverfront concerts and downtown nightlife. It’s also peak season for travelers heading to the Smokies.
  • Winter (December – February): Light snow and quiet downtown charm make winter a good time for indoor attractions and cozy cafes.

Top things to see and do in Knoxville 

Knoxville combines Appalachian charm with downtown culture, creating a destination with something for every kind of traveler.

  • Market Square: The walkable district is filled with restaurants, live music and seasonal farmers markets.
  • Ijams Nature Center: A favorite for hiking, paddling and connecting with nature, this center is just minutes from downtown.
  • Knoxville Museum of Art: Art lovers will enjoy this museum’s regional works and free admission.
  • World's Fair Park: Known for the Sunsphere, the park hosts events throughout the year, including music festivals and cultural fairs.
  • Old City: The historic area that now buzzes with bars, galleries and late-night venues that are ideal for evening downtime.

Booking your trip to Knoxville with American Airlines

Whether you're planning meetings in the city or a weekend exploring Tennessee trails, you’ll be welcomed by Knoxville's Southern hospitality and energy. American is here to support your trip to Knoxville, so get ready to book today.

Knoxville routes with American Airlines