American Airlines flights to Panama City from $237*

Popular flights to Panama City on American Airlines

American Airlines offers flights to Panama City (ECP) from cities across the U.S. Nonstop and connecting options are available depending on the route and travel dates, with schedules and fares that vary throughout the year.

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  • Chicago (ORD)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $315Fare subject to changes
    Updated: 37 minutes ago
    Round trip
    Economy

    Providence (PVD)to

    Panama City (ECP)
    08/05/26 - 08/12/26
    from
    $333Fare subject to changes
    Updated: 13 hours ago
    Round trip
    Economy

    Austin (AUS)to

    Panama City (ECP)
    08/14/26 - 08/21/26
    from
    $257Fare subject to changes
    Updated: 18 minutes ago
    Round trip
    Economy

    Saint Louis (STL)to

    Panama City (ECP)
    09/15/26 - 09/22/26
    from
    $237Fare subject to changes
    Updated: 17 minutes ago
    Round trip
    Economy

  • San Jose (SJC)to

    Panama City (ECP)
    09/08/26 - 09/15/26
    from
    $375Fare subject to changes
    Updated: 7 hours ago
    Round trip
    Economy

    Fayetteville (XNA)to

    Panama City (ECP)
    09/02/26 - 09/09/26
    from
    $291Fare subject to changes
    Updated: 13 hours ago
    Round trip
    Economy

    Cleveland (CLE)to

    Panama City (ECP)
    09/28/26 - 10/05/26
    from
    $317Fare subject to changes
    Updated: 7 hours ago
    Round trip
    Economy

    Indianapolis (IND)to

    Panama City (ECP)
    07/28/26 - 08/04/26
    from
    $301Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

  • Los Angeles (LAX)to

    Panama City (ECP)
    09/15/26 - 09/22/26
    from
    $355Fare subject to changes
    Updated: 4 minutes ago
    Round trip
    Economy

    Nashville (BNA)to

    Panama City (ECP)
    08/17/26 - 08/24/26
    from
    $247Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Phoenix (PHX)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $311Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Washington, D.C. (WAS)to

    Panama City (ECP)
    08/22/26 - 08/29/26
    from
    $267Fare subject to changes
    Updated: 13 hours ago
    Round trip
    Economy

  • Denver (DEN)to

    Panama City (ECP)
    08/05/26 - 08/12/26
    from
    $317Fare subject to changes
    Updated: 10 hours ago
    Round trip
    Economy

    New York (LGA)to

    Panama City (ECP)
    09/05/26 - 09/11/26
    from
    $300Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    Pittsburgh (PIT)to

    Panama City (ECP)
    09/02/26 - 09/09/26
    from
    $317Fare subject to changes
    Updated: 9 hours ago
    Round trip
    Economy

    Seattle (SEA)to

    Panama City (ECP)
    09/21/26 - 09/28/26
    from
    $355Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Find deals on flights to Panama City

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Dallas (DFW)to

Panama City (ECP)
08/15/26 - 08/22/26

Round trip

Economy

from
$257Fare subject to changes
Updated: 12 hours ago

Washington, D.C. (DCA)to

Panama City (ECP)
09/15/26 - 09/22/26

Round trip

Economy

from
$267Fare subject to changes
Updated: 8 minutes ago

Charlotte (CLT)to

Panama City (ECP)
08/15/26 - 08/22/26

Round trip

Economy

from
$373Fare subject to changes
Updated: 2 hours ago

Philadelphia (PHL)to

Panama City (ECP)
08/18/26 - 08/25/26

Round trip

Economy

from
$375Fare subject to changes
Updated: 46 minutes ago

Chicago (ORD)to

Panama City (ECP)
08/18/26 - 08/25/26

Round trip

Economy

from
$315Fare subject to changes
Updated: 37 minutes ago

Providence (PVD)to

Panama City (ECP)
09/21/26 - 09/28/26

Round trip

Economy

from
$333Fare subject to changes
Updated: 13 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Finding cheap flights to Panama City

Looking for lower fares on flights to Panama City? Here are a few ways to save.

  • Book early: Booking 1 to 3 months ahead can help you find lower fares
  • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
  • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

Earn up to $400 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

Upgrade your flight with Main Cabin Extra

Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

  • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
  • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
  • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

Discover how Main Cabin Extra can enhance your trip.

American Airlines flights to Panama City

Panama City routes with American Airlines