American Airlines flights from Manhattan to San Diego

Recent searches for flights from Manhattan to San Diego

Sep 2026
From$434*
Updated: 1 hour ago
Round tripIEconomy
Oct 2026
From$354*
Updated: 1 hour ago
Round tripIEconomy
Nov 2026
From$354*
Updated: 1 hour ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $434
cmp-daily-histogram-bars-legend-max-price-aria-label $792
Displaying fares for September-2026
  • MHK–SAN, 09/01/26 – 09/08/26: From $514
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    SEP

  • MHK–SAN, 09/02/26 – 09/09/26: From $514
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  • MHK–SAN, 09/03/26 – 09/10/26: From $644
    03

    Th

  • MHK–SAN, 09/04/26 – 09/11/26: From $644
    04

    Fr

  • MHK–SAN, 09/05/26 – 09/12/26: From $673
    05

    Sa

  • MHK–SAN, 09/06/26 – 09/13/26: From $644
    06

    Su

  • MHK–SAN, 09/07/26 – 09/14/26: From $792
    07

    Mo

  • MHK–SAN, 09/08/26 – 09/15/26: From $673
    08

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  • MHK–SAN, 09/09/26 – 09/16/26: From $434
    09

    We

  • MHK–SAN, 09/10/26 – 09/17/26: From $580
    10

    Th

  • MHK–SAN, 09/11/26 – 09/18/26: From $716
    11

    Fr

  • MHK–SAN, 09/12/26 – 09/19/26: From $434
    12

    Sa

  • MHK–SAN, 09/13/26 – 09/20/26: From $792
    13

    Su

  • MHK–SAN, 09/14/26 – 09/21/26: From $792
    14

    Mo

  • MHK–SAN, 09/15/26 – 09/22/26: From $514
    15

    Tu

  • MHK–SAN, 09/16/26 – 09/23/26: From $514
    16

    We

  • MHK–SAN, 09/17/26 – 09/24/26: From $644
    17

    Th

  • MHK–SAN, 09/18/26 – 09/25/26: From $644
    18

    Fr

  • MHK–SAN, 09/19/26 – 09/26/26: From $514
    19

    Sa

  • MHK–SAN, 09/20/26 – 09/27/26: From $644
    20

    Su

  • MHK–SAN, 09/21/26 – 09/28/26: From $741
    21

    Mo

  • MHK–SAN, 09/22/26 – 09/29/26: From $514
    22

    Tu

  • MHK–SAN, 09/23/26 – 09/30/26: From $514
    23

    We

  • MHK–SAN, 09/24/26 – 10/01/26: From $552
    24

    Th

  • MHK–SAN, 09/25/26 – 10/02/26: From $633
    25

    Fr

  • MHK–SAN, 09/26/26 – 10/03/26: From $593
    26

    Sa

  • MHK–SAN, 09/27/26 – 10/04/26: From $716
    27

    Su

  • MHK–SAN, 09/28/26 – 10/05/26: From $552
    28

    Mo

  • MHK–SAN: cmp-view-offers-disclaimer. Find Offers
    29

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  • MHK–SAN: cmp-view-offers-disclaimer. Find Offers
    30

    We

    • range$434-$792

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Manhattan to San Diego flights

    $
    keyboard_arrow_down

    Manhattan (MHK)to

    San Diego (SAN)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/24/26 - 10/31/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/13/26 - 10/20/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/14/26 - 10/21/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    Manhattan (MHK)to

    San Diego (SAN)
    10/28/26 - 11/04/26

    Round trip

    Economy

    from
    $354Fare subject to changes
    Updated: 1 hour ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Manhattan to San Diego

    Looking for lower fares on your trip from Manhattan to San Diego? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Manhattan to San Diego