American Airlines flights from Key West to San Diego

Recent searches for flights from Key West to San Diego

Aug 2026
From$555*
Updated: 9 hours ago
Round tripIEconomy
Sep 2026
From$492*
Updated: 18 hours ago
Round tripIEconomy
Oct 2026
From$439*
Updated: 9 hours ago
Round tripIEconomy
cmp-daily-histogram-bars-legend-min-price-aria-label $497
cmp-daily-histogram-bars-legend-max-price-aria-label $969
Displaying fares for August-2026
  • EYW–SAN, 08/12/26 – 08/19/26: From $555
    12

    We

    AUG

  • EYW–SAN, 08/13/26 – 08/20/26: From $759
    13

    Th

  • EYW–SAN, 08/14/26 – 08/21/26: From $693
    14

    Fr

  • EYW–SAN, 08/15/26 – 08/22/26: From $555
    15

    Sa

  • EYW–SAN, 08/16/26 – 08/23/26: From $969
    16

    Su

  • EYW–SAN, 08/17/26 – 08/24/26: From $764
    17

    Mo

  • EYW–SAN, 08/18/26 – 08/25/26: From $555
    18

    Tu

  • EYW–SAN, 08/19/26 – 08/26/26: From $555
    19

    We

  • EYW–SAN, 08/20/26 – 08/27/26: From $665
    20

    Th

  • EYW–SAN, 08/21/26 – 08/28/26: From $665
    21

    Fr

  • EYW–SAN, 08/22/26 – 08/29/26: From $555
    22

    Sa

  • EYW–SAN, 08/23/26 – 08/30/26: From $731
    23

    Su

  • EYW–SAN, 08/24/26 – 08/31/26: From $647
    24

    Mo

  • EYW–SAN, 08/25/26 – 09/01/26: From $555
    25

    Tu

  • EYW–SAN, 08/26/26 – 09/02/26: From $555
    26

    We

  • EYW–SAN, 08/27/26 – 09/03/26: From $731
    27

    Th

  • EYW–SAN, 08/28/26 – 09/04/26: From $617
    28

    Fr

  • EYW–SAN, 08/29/26 – 09/05/26: From $555
    29

    Sa

  • EYW–SAN, 08/30/26 – 09/06/26: From $711
    30

    Su

  • EYW–SAN, 08/31/26 – 09/07/26: From $617
    31

    Mo

  • EYW–SAN, 09/01/26 – 09/08/26: From $555
    01

    Tu

    SEP

  • EYW–SAN, 09/02/26 – 09/09/26: From $555
    02

    We

  • EYW–SAN, 09/03/26 – 09/10/26: From $645
    03

    Th

  • EYW–SAN, 09/04/26 – 09/11/26: From $571
    04

    Fr

  • EYW–SAN, 09/05/26 – 09/12/26: From $497
    05

    Sa

  • EYW–SAN, 09/06/26 – 09/13/26: From $685
    06

    Su

  • EYW–SAN, 09/07/26 – 09/14/26: From $878
    07

    Mo

  • EYW–SAN, 09/08/26 – 09/15/26: From $643
    08

    Tu

  • EYW–SAN: cmp-view-offers-disclaimer. Find Offers
    09

    We

  • EYW–SAN: cmp-view-offers-disclaimer. Find Offers
    10

    Th

  • EYW–SAN, 09/11/26 – 09/18/26: From $545
    11

    Fr

    • range$497-$969

    DisclaimerFares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Fares listed may be Basic Economy, which class is subject to additional terms and conditions. Additional baggage fees and charges for optional products and services may apply.

    Find deals on Key West to San Diego flights

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    keyboard_arrow_down

    Key West (EYW)to

    San Diego (SAN)
    10/20/26 - 10/27/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    10/27/26 - 11/03/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    10/31/26 - 11/07/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    10/06/26 - 10/13/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    11/03/26 - 11/10/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    11/07/26 - 11/14/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    10/21/26 - 10/28/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    Key West (EYW)to

    San Diego (SAN)
    11/04/26 - 11/11/26

    Round trip

    Economy

    from
    $439Fare subject to changes
    Updated: 9 hours ago

    *Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

    Finding cheap flights from Key West to San Diego

    Looking for lower fares on your trip from Key West to San Diego? Here are a few ways to save.

    • Book early: Booking 1 to 3 months ahead can help you find lower fares
    • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
    • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

    Earn up to $500 back on your next American Airlines flight plus, 30,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

    Upgrade your flight with Main Cabin Extra

    Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

    • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
    • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
    • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

    Discover how Main Cabin Extra can enhance your trip.

    American Airlines flights from Key West to San Diego