American Airlines flights to Des Moines from $234*

Popular flights to Des Moines on American Airlines

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  • Philadelphia (PHL)to

    Des Moines (DSM)
    12/20/25 - 12/25/25
    from
    $344Fare subject to changes
    Updated: 3 hours ago
    Round trip
    Economy

    Charlotte (CLT)to

    Des Moines (DSM)
    12/22/25 - 12/30/25
    from
    $569Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    Los Angeles (LAX)to

    Des Moines (DSM)
    01/08/26 - 01/12/26
    from
    $316Fare subject to changes
    Updated: 4 hours ago
    Round trip
    Economy

    Miami (MIA)to

    Des Moines (DSM)
    12/19/25 - 12/21/25
    from
    $551Fare subject to changes
    Updated: 23 hours ago
    Round trip
    Economy

  • Orlando (MCO)to

    Des Moines (DSM)
    01/19/26 - 01/23/26
    from
    $474Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    Austin (AUS)to

    Des Moines (DSM)
    02/26/26 - 02/28/26
    from
    $271Fare subject to changes
    Updated: 1 hour ago
    Round trip
    Economy

    San Francisco (SFO)to

    Des Moines (DSM)
    12/24/25 - 12/30/25
    from
    $743Fare subject to changes
    Updated: 17 hours ago
    Round trip
    Economy

    Washington, D.C. (WAS)to

    Des Moines (DSM)
    12/25/25 - 01/01/26
    from
    $325Fare subject to changes
    Updated: 5 hours ago
    Round trip
    Economy

  • Jackson (JAN)to

    Des Moines (DSM)
    12/15/25 - 12/18/25
    from
    $617Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    Nashville (BNA)to

    Des Moines (DSM)
    02/05/26 - 02/09/26
    from
    $281Fare subject to changes
    Updated: 22 hours ago
    Round trip
    Economy

    Columbus (CMH)to

    Des Moines (DSM)
    01/21/26 - 01/26/26
    from
    $291Fare subject to changes
    Updated: 4 hours ago
    Round trip
    Economy

    Harrisburg (MDT)to

    Des Moines (DSM)
    01/11/26 - 01/16/26
    from
    $368Fare subject to changes
    Updated: 1 hour ago
    Round trip
    Economy

  • Boston (BOS)to

    Des Moines (DSM)
    01/03/26 - 01/05/26
    from
    $371Fare subject to changes
    Updated: 20 hours ago
    Round trip
    Economy

    Pittsburgh (PIT)to

    Des Moines (DSM)
    01/14/26 - 01/15/26
    from
    $299Fare subject to changes
    Updated: 3 hours ago
    Round trip
    Economy

    Savannah (SAV)to

    Des Moines (DSM)
    01/04/26 - 01/11/26
    from
    $397Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

    Wilmington (ILM)to

    Des Moines (DSM)
    01/02/26 - 01/09/26
    from
    $259Fare subject to changes
    Updated: 47 minutes ago
    Round trip
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Find deals on flights to Des Moines

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Phoenix (PHX)to

Des Moines (DSM)
02/13/26 - 02/17/26

Round trip

Economy

from
$260Fare subject to changes
Updated: 23 hours ago

Dallas (DFW)to

Des Moines (DSM)
01/27/26 - 01/29/26

Round trip

Economy

from
$353Fare subject to changes
Updated: 18 hours ago

Washington, D.C. (DCA)to

Des Moines (DSM)
05/19/26 - 05/24/26

Round trip

Economy

from
$387Fare subject to changes
Updated: 10 hours ago

Philadelphia (PHL)to

Des Moines (DSM)
03/30/26 - 04/25/26

Round trip

Economy

from
$352Fare subject to changes
Updated: 2 hours ago

Los Angeles (LAX)to

Des Moines (DSM)
03/23/26 - 03/25/26

Round trip

Economy

from
$470Fare subject to changes
Updated: 18 hours ago

Charlotte (CLT)to

Des Moines (DSM)
06/19/26 - 06/21/26

Round trip

Economy

from
$709Fare subject to changes
Updated: 23 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights to Des Moines
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Des Moines routes with American Airlines